![]() ![]() 12 Contrary to the retinal and optic nerve head vasculature, choroid vessels are also subject to autonomic regulation. These experiments explored the mechanisms underlying hypercapnia-induced vasodilatation explained by a reduction in pH 11 and an increase in nitric oxide (NO) availability. 9 Our recent study on ocular microcirculation in OSA 10 with laser Doppler flowmetry (LDF) showed that OSA patients without cardiovascular comorbidities exhibited normal choroidal vasoreactivity in response to hyperoxia and hypercapnia. ( number, NCT00874913.)Īll these potential cardiovascular consequences associated with OSA may also interact with ocular vascular regulation, as suggested by the relation between OSA and nonarteritic anterior ischemic optic neuropathy, 7 central serous chorioretinopathy, 8 and glaucomatous optic neuropathy. This study strongly suggests that the regulation of choroidal blood flow, which depends on the orthosympathetic and parasympathetic systems, is unaltered in men with OSA who have no comorbidities. Choroidal blood flow responses to exercise and posture changes were unchanged after 6 to 9 months of continuous positive airway pressure treatment. In both populations, no significant change in choroidal blood flow or vascular resistance was found during the posture change. ![]() From the sitting to the supine position, a significant decrease in mean arterial pressure occurred in both groups (10.9%–13.4% P < 0.001). ![]() A significant linear relationship ( P = 0.0003) was noted between choroidal vascular resistance and the OPP changes during exercise in OSA patients and control subjects. Choroidal reactivity was assessed by laser Doppler flowmetry, which measured subfoveal choroidal blood flow.ĭuring exercise, blood pressure parameters increased significantly within the same range, with a similar profile over time in OSA patients and control subjects. All subjects underwent sleep studies and cardiovascular phenotyping (24-hour blood pressure monitoring, arterial stiffness measurements, and cardiac and carotid echography). Healthy men were matched 1:1 for body mass index, sex, and age with patients with newly diagnosed OSA without cardiovascular comorbidities. It was hypothesized that choroidal vascular reactivity in response to isometric exercise and posture changes could be altered in OSA patients. Exercise and posture changes can be used to manipulate blood pressure, ocular perfusion pressure (OPP), or both. Never disregard your doctor’s medical advice or delay in seeking it as a result of something on this site. Reliance on any information provided by The Basketball Doctors is solely at your own risk.Obstructive sleep apnea (OSA) syndrome generates hypertension, atherosclerosis, and endothelial and autonomic dysfunction, which may mutually interact with ocular vascular regulation. Talk with your healthcare provider about any questions you may have regarding a medical condition. The information is not intended to be physical therapy, medicaladvice, or treatment. Any reference to or mention of any particular diagnoses or dysfunctions is intended for informational purposes only and not an attempt to diagnose your particular problems.Īlways seek the advice of your physician or other qualified healthcare providers before starting any new treatment or discontinuing an existing treatment. The information provided in the videos are by no means complete or exhaustive, and, therefore, does not apply to all conditions, disorders, and health-related issues. The Basketball Doctors are unable to provide any warranty concerning the accuracy or completeness of any information contained herein. The Basketball Doctors assume no responsibility or liability for any injury, loss, or damage incurred as a result of any use or reliance upon the information and material contained within or downloaded from its website. ![]()
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